The Medical Research Future Fund (MRFF) – Primary Health Care Research Initiative (PHCRI) aims to enable or support an increase in Australia’s evidence base in primary health care through research to improve service delivery and patient outcomes, and translate this knowledge into action. The objective of this grant opportunity is to provide grants of financial assistance to support medical research and medical innovation projects that: investigate and trial approaches, including adapting successful trials, to advance equity in primary health care services. are co-designed with primary health care services and consumers. Two streams of funding are available: Stream 1 (Targeted Call for Research): The organisation undertaking the majority of the research must be located in any area according to the Modified Monash Model (MM1-7). Stream 2 (Targeted Call for Research): The organisation undertaking the majority of the research is located in, and the Chief Investigator A and 50% or more of all Chief Investigators, and all research participants, are primarily resident in a regional, rural or remote area according to the Modified Monash Model (MM2-7). The intended outcome of the research is to improve the health and wellbeing of Australians by advancing equity in primary health care services. Applicants to this grant opportunity must propose to conduct research that delivers against the above objectives and those of the Primary Health Care Research Initiative. This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health, Disability and Ageing. Further information on the Medical Research Future Fund is available from the Department of Health, Disability and Ageing's website. A list of Eligible Organisations can be found on the NHMRC List of MRFF Eligible Organisations webpage. Eligibility: Applications will only be accepted from approved MRFF Eligible Organisations. A list of approved MRFF Eligible Organisations is available from the MRFF Eligible Organisations List on the NHMRC website. Applications must satisfy all the requirements set out in the MRFF – PHCRI – 2026 Primary Health Care Research Grant Opportunity Guidelines. Grant Activity Timeframe: Within 5 years from the commencement date specified in the grant schedule. Total Amount Available (AUD): $20,000,000.00 Estimated Grant Value (AUD): From $0.00 to $3,000,000.00 Instructions for Application Submission: Applicants are advised to read the Grant Guidelines thoroughly and liaise with the MRFF Eligible Organisation that will submit the application to identify any specific requirements that the Organisation might have. Applications must be submitted electronically using NHMRC’s online granting system (Sapphire). Other Instructions: Minimum Data closes at 5:00pm (ACT Local Time) on 7 October 2026 Questions should be submitted no later than 1:00pm (ACT Local Time) on 28 October 2026.